a. Higher than expected mortality. An increase in the percentage of mortality as a direct result of protocol procedures (e.g., protocol predicts 15% death during a surgical procedure expected, but 30% death is occurring). b.Unexpected death of an animal. An animal dies either as a result of an approved procedure (e.g., deathduring anesthesia*, administration of a drug) or an animal dies due to illness or injury unrelated to a protocolprocedure (e.g., infectious disease, injury caused by aggression). *For rodents: Only report >5 fatalities/100animals anesthetized/strain. c.Unexpected euthanasia of an animal. This does not include euthanasia as part of the protocol or for criteriafor moribundity that are reasonably expected as part of the protocol procedures and are listed on the protocol(e.g., development of a tumor in mice known to spontaneously develop tumors). d.Unexpected clinical signs. An animal develops clinical signs as result of an approved procedure (e.g.,administration of a drug causes unexpected diarrhea) or due to illness or injury unrelated to a protocolprocedure. This does not include clinical signs that are reasonably expected as part of the protocol proceduresand are listed on the protocol (e.g., frequent urination in animals with diabetes). e.Observation of a new negative phenotype in trangenics. Negative phenotypes may be observed whenstrains are acquired from a new source, two strains are crossed, or a transgenic strain is developed. Negativephenotypes include early mortality, spontaneous development of tumors, neurological conditions, blindness,skin conditions, reduced fertility, etc. f.A condition that jeopardizes the health or well-being of animals. This includes accidents, mechanicalfailures, and natural disasters that results in harm or death to animals. g.Frequent incidents of drowning or near-drowning of rodents in cages as a result of issues with water source. h.Accident during animal transport resulting in either an injury (animal is treated or euthanized), or death. i.Other. The incident does not fit one of the above categories, or you are unsure which category to choose.